资讯内容 Content

[ADA2011]外周动脉疾病的机制及管理
——Brian H.Annex专访
国际糖尿病网版权所有,谢绝任何形式转载,侵犯版权者必予法律追究。

作者:B.H.Annex 2011/6/17 17:50:00    加入收藏
内容概要:Brian H.Annex 弗尼吉亚大学心血管科教授,研究领域涵盖外周动脉疾病的血管形成术、基因治疗等方面。

   Brian H.Annex  弗尼吉亚大学心血管科教授,研究领域涵盖外周动脉疾病的血管形成术、基因治疗等方面。

    <International Diabetes>: Peripheral arterial disease is a common chronic complication of type 2 diabetes and a significant reason for diabetic foot. What is the latest pathogenesis of PAD?

   《国际糖尿病》:外周动脉疾病(PAD)是2型糖尿病的一种常见的慢性并发症,是糖尿病足的重要原因之一, PAD最新的发病机制是什么?
    Prof.Annex: That is a very interesting question and it can actually be answered in several different directions. We know very clearly that peripheral arterial disease is caused by blockages in the leg arteries – the arteries that supply blood to the lower extremity and the foot. That part is pretty well known. What really is not known is why does diabetes cause blockages to be formed in that area. And then the other side of the question, related to the foot ulcer (which is the more extreme form where you lack blood flow to the leg), how does diabetes actually affect the ability of the body to compensate for or accommodate the blockages and why are diabetics in particular so bad at forming collateral blood vessels? The questions really come down to understanding why diabetes is such a profound risk factor for developing blockages and then once the blockages are formed, why diabetes so limits our body’s ability to repair or work around those blockages. So it is always a work in progress. I think we are learning more and more every day. I think we are continuing to learn on both human studies and preclinical studies. We have a long way to go but slowly but surely I hope we are going to start unraveling these questions.

    Annex教授:这是一个让人非常感兴趣的问题,实际上可以从几个不同的方向来回答。我们非常清楚地知道,外周动脉疾病是由腿部动脉(向下肢和足部供血的动脉)阻塞引起的。这部分已经众所周知。未知的是为何糖尿病导致该区域形成阻塞。然后,问题的另一方面与足部溃疡有关(这是到腿部的血流缺乏的更为末端的形式)。糖尿病实际上如何影响身体代偿或适应阻塞的能力以及为何糖尿病患者在形成侧支血管上如此槽糕?这些问题最终归结为理解对发生阻塞来说,为何糖尿病是一项如此严重的危险因素,以及其后一旦阻塞形成,为何糖尿病如此限制我们机体修复或解决这些阻塞的能力。因此它始终是一个处于进展中的工作。我认为我们每天都在认识的越来越多。我想我们正在通过人类研究和临床前期研究不断认识。我们有很长的路要走,虽然缓慢,但是坚定,我希望我们将会开始阐明这些问题。



[1]  [2]  [3]  [4]  下一页

 延伸阅读
网站用户: 靳素梅 时间:2011/9/1 22:30:23
很期待这一结果 的出现。

注册

网友评论仅供其表达个人看法,并不表明国际糖尿病同意其观点或证实其描述。 发表评论需登陆

相关幻灯

相关视频

 
关于本站 | 设为首页 | 加入收藏 | 站长邮箱 | 友情链接 | 版权申明

国际糖尿病(www.idiabetes.com.cn)对刊载的所有文章、视频、幻灯、音频等资源拥有全部版权。未经本站许可,不得转载。

国际糖尿病 版权所有  2008-2018 idiabetes.com.cn  All Rights Reserved